Datamethods is a discussion site where data methodologists meet each other and subject matter experts including clinical trialists and clinical researchers. Its development is documented here. Datamethods is provided by the Department of Biostatistics, Vanderbilt University School of Medicine. I have written some short articles on the site, listed below. Responder analysis: Loser x 4 Problems with NNT Should we ignore covariate imbalance and stop presenting a stratified ‘table one’ for randomized trials?

Improving Research Through Safer Learning from Data

What are the major elements of learning from data that should inform the research process? How can we prevent having false confidence from statistical analysis? Does a Bayesian approach result in more honest answers to research questions? Is learning inherently subjective anyway, so we need to stop criticizing Bayesians’ subjectivity? How important and possible is pre-specification? When should replication be required? These and other questions are discussed.

Fundamental Principles of Statistics

There are many principles involved in the theory and practice of statistics, but here are the ones that guide my practice the most. Use methods grounded in theory or extensive simulation Understand uncertainty, and realize that the most honest approach to inference is a Bayesian model that takes into account what you don’t know (e.g., Are variances equal? Is the distribution normal? Should an interaction term be in the model?