Datamethods is a discussion site where data methodologists meet each other and subject matter experts including clinical trialists and clinical researchers. Its development is documented here. Datamethods is provided by the Department of Biostatistics, Vanderbilt University School of Medicine. I have written some short articles on the site, listed below. Responder analysis: Loser x 4 Problems with NNT Should we ignore covariate imbalance and stop presenting a stratified ‘table one’ for randomized trials?

Clinicians' Misunderstanding of Probabilities Makes Them Like Backwards Probabilities Such As Sensitivity, Specificity, and Type I Error

Optimum decision making in the presence of uncertainty comes from probabilistic thinking. The relevant probabilities are of a predictive nature: P(the unknown given the known). Thresholds are not helpful and are completely dependent on the utility/cost/loss function. Corollary: Since p-values are P(someone else’s data are more extreme than mine if H0 is true) and we don’t know whether H0 is true, it is a non-predictive probability that is not useful for decision making.