# My Journey From Frequentist to Bayesian Statistics

The difference between Bayesian and frequentist inference in a nutshell:With Bayes you start with a prior distribution for θ and given your data make an inference about the θ-driven process generating your data (whatever that process happened to be), to quantify evidence for every possible value of θ. With frequentism, you make assumptions about the process that generated your data and infinitely many replications of them, and try to build evidence for what θ is not. | |

Frequentism is about the data generating process. Bayes is about the θ generating process, and about the data generated. | |

Far better an approximate answer to the right question, which is often vague, than the exact answer to the wrong question, which can always be made precise –
John TukeyApproximate: My prior distribution disagrees with yours, so my posterior probability that the treatment works is 0.02 less than yours (and BTW the p-value from the frequentist analysis is only accurate to ±0.015 in this non-normal case)Right question: Does the treament work more than a trivial amount?Exact answer: Under the simplifying assumption that H_{0} is true we can actually compute exact p-values in ^{1}/_{10} of the models we useWrong question: How surprising is our result if the treatment has no effect at all? | |

Any frequentist criticizing the Bayesian paradigm for requiring one to choose a prior distribution must recognize that she has a possibly more daunting task: to completely specify the experimental design, sampling scheme, and data generating process that were actually used and would be infinitely replicated to allow p-values and confidence limits to be computed. | |

Those who criticize Bayes for having to choose a prior must remember that the frequentist approach leads to different p-values on the same data depending on how intentions are handled (e.g., observing 6 heads out of 10 tosses vs. having to toss 10 times to observe 6 heads; accounting for earlier inconsequential data looks in sequential testing). | |

When was the last time you observed a sampling distribution, empirically and objectively? When was the last time you saw someone justify their choice of a sampling distribution, or tested it? – Stephen Martin | |

Null hypothesis testing is simple because it kicks down the road the gymnastics needed to subjectively convert observations about data to evidence about parameters. | |

Subjective Bayesian priors are explicit. Subjective frequentist interpretation of a rather meaningless probability is not and thus not subject to informed challenge. – Paul Pharoah | |

Type I error for smoke detector: probability of alarm given no fire=0.05 Bayesian: probability of fire given current air characteristics Frequentist smoke alarm designed as most research is done: Set the alarm trigger so as to have a 0.8 chance of detecting an inferno Advantage of actionable evidence quantification:Set the alarm to trigger when the posterior probability of a fire exceeds 0.02 while at home and at 0.01 while away | |

Reject a specific null, and then argue for an arbitrary alternative. It’s pretty remarkable that so few people see how absurd this procedure is. –
JP de Ruiter | |

If you tossed a coin 100 times resulting in 60 heads, would you rather know the probability of getting > 59 heads out of 100 tosses if the coin happened to be fair, or the probability it is fair given exactly 60 heads? The frequentist approach is alluring because of the minimal work in carrying out a test of the null hypothesis θ=½. But the Bayesian approach provides a direct answer to the second question, and requires you to think. What is an “unfair” coin? Is it θ outside of [0.49, 0.51]? What is the world view of coins, e.g., is someone likely to provide a coin that is easily detectable as unfair because its θ=0.6? Was the coin chosen at random or handed to us? | |

The null-hypothesis significance test treats ‘acceptance’ or ‘rejection’ of a hypothesis as though these were decisions one makes. But a hypothesis is not something, like a piece of pie offered for dessert, which can be accepted or rejected by a voluntary physical action. Acceptance or rejection of a hypothesis is a cognitive process, a degree of believing or disbelieving which, if rational, is not a matter of choice but determined solely by how likely it is, given the evidence, that the hypothesis is true. – WW Rozeboom, 1960, pp. 422-423 in EJ Wagenmakers and Q Gronau. | |

The only way to make frequentist methods comprehensible is to obfuscate them, and the only way to be fully accurate is to make them incomprehensible. | |

The frequentist type I error is the probability of asserting an effect when there is no effect, and is independent of data. One minus the Bayesian conditional probability of an effect given the data is the probability the treatment doesn’t work whether or not you assert that it does. | |

Judging a Bayesian procedure by its type I probability α is equivalent to judging a gambler by the fraction of potential losses in which he | |

Someone demanding that a Bayesian procedure preserve type I error, e.g. that P(posterior probability of positive effect > 0.95 given no effect) ≤ α, should be demanded to show their frequentist procedure yields decisons as good as those driven by the Bayesian P(effect > 0 given data, prior). | |

A paradigm that cannot compute the probability that a treatment works cannot control the probability of making a decision error, e.g., the probability that a treatment actually doesn’t work when you act as though it does. | |

The only agents that use frequentist statistics are frequentists statisticians when they practice frequentist statistics. In the real world, evolution rooted out those agents who willfully ignore prior knowledge to address irrelevant questions in an incoherent fashion. – EJ Wagenmakers | |

In arguing for progressive (and pragmatic) attitudes in statistical theory and practice [in overcoming inertia moving beyond Frequentism and embracing Bayesianism] it may be well to point to how other fields, such as Economics and Physics, fields that describe how the world works, have ineluctably had major paradigm shifts. In every major field—if it is an intellectually honest one—there is a moment where we have to “un-learn” what we have been inculcated in, conculcate operative premises, and retool our paradigms. There is no reason to expect that Statistics is different. – Drew Levy |

If I had been taught Bayesian modeling before being taught the frequentist paradigm, I’m sure I would have always been a Bayesian. I started becoming a Bayesian about 1994 because of an influential paper by David Spiegelhalter and because I worked in the same building at Duke University as Don Berry. Two other things strongly contributed to my thinking: difficulties explaining p-values and confidence intervals (especially the latter) to clinical researchers, and difficulty of learning group sequential methods in clinical trials. When I talked with Don and learned about the flexibility of the Bayesian approach to clinical trials, and saw Spiegelhalter’s embrace of Bayesian methods because of its problem-solving abilities, I was hooked. [Note: I’ve heard Don say that he became Bayesian after multiple attempts to teach statistics students the exact definition of a confidence interval. He decided the concept was defective.]

At the time I was working on clinical trials at Duke and started to see that multiplicity adjustments were arbitrary. This started with a clinical trial coordinated by Duke in which low dose and high dose of a new drug were to be compared to placebo, using an alpha cutoff of 0.03 for each comparison to adjust for multiplicity. The comparison of high dose with placebo resulted in a p-value of 0.04 and the trial was labeled completely “negative” which seemed problematic to me. [Note: the p-value was two-sided and thus didn’t give any special “credit” for the treatment effect coming out in the right direction.]

I began to see that the hypothesis testing framework wasn’t always the best approach to science, and that in biomedical research the typical hypothesis was an artificial construct designed to placate a reviewer who believed that an NIH grant’s specific aims must include null hypotheses. I saw the contortions that investigators went through to achieve this, came to see that questions are more relevant than hypotheses, and estimation was even more important than questions.

With Bayes, estimation is emphasized. I very much like Bayesian modeling instead of hypothesis testing. I saw that a large number of clinical trials were incorrectly interpreted when p>0.05 because the investigators involved failed to realize that a p-value can only provide evidence against a hypothesis. Investigators are motivated by “we spent a lot of time and money and must have gained something from this experiment.” The classic “ absence of evidence is not evidence of absence” error results, whereas with Bayes it is easy to estimate the probability of similarity of two treatments. Investigators will be surprised to know how little we have learned from clinical trials that are not huge when p>0.05.

I listened to many discussions of famous clinical trialists debating what should be the primary endpoint in a trial, the co-primary endpoint, the secondary endpoints, co-secondary endpoints, etc. This was all because of their paying attention to alpha-spending. I realized this was all a game.

I came to not believe in the possibility of infinitely many repetitions of identical experiments, as required to be envisioned in the frequentist paradigm. When I looked more thoroughly into the multiplicity problem, and sequential testing, and I looked at Bayesian solutions, I became more of a believer in the approach. I learned that posterior probabilities have a simple interpretation independent of the stopping rule and frequency of data looks. I got involved in working with the FDA and then consulting with pharmaceutical companies, and started observing how multiple clinical endpoints were handled. I saw a closed testing procedures where a company was seeking a superiority claim for a new drug, and if there was insufficient evidence for such a claim, they wanted to seek a non-inferiority claim on another endpoint. They developed a closed testing procedure that when diagrammed truly looked like a train wreck. I felt there had to be a better approach, so I sought to see how far posterior probabilities could be pushed. I found that with MCMC simulation of Bayesian posterior draws I could quite simply compute probabilities such as P(any efficacy), P(efficacy more than trivial), P(non-inferiority), P(efficacy on endpoint A and on either endpoint B or endpoint C), and P(benefit on more than 2 of 5 endpoints). I realized that frequentist multiplicity problems came from the chances you give data to be more extreme, not from the chances you give assertions to be true.

I enjoy the fact that posterior probabilities define their own error
probabilities, and that they count not only inefficacy but also harm.
If P(efficacy)=0.97, P(no effect or harm)=0.03. This is the
“regulator’s regret”, and type I error is not the error of major
interest (is it really even an ‘error’?). One minus a p-value is P(data
in general are less extreme than that observed if H_{0} is true) which is
the probability of an event I’m not that interested in.

The extreme amount of time I spent analyzing data led me to understand other problems with the frequentist approach. Parameters are either in a model or not in a model. We test for interactions with treatment and hope that the p-value is not between 0.02 and 0.2. We either include the interactions or exclude them, and the power for the interaction test is modest. Bayesians have a prior for the differential treatment effect and can easily have interactions “half in” the model. Dichotomous irrevocable decisions are at the heart of many of the statistical modeling problems we have today. I really like penalized maximum likelihood estimation (which is really empirical Bayes) but once we have a penalized model all of our frequentist inferential framework fails us. No one can interpret a confidence interval for a biased (shrunken; penalized) estimate. On the other hand, the Bayesian posterior probability density function, after shrinkage is accomplished using skeptical priors, is just as easy to interpret as had the prior been flat. For another example, consider a categorical predictor variable that we hope is predicting in an ordinal (monotonic) fashion. We tend to either model it as ordinal or as completely unordered (using k-1 indicator variables for k categories). A Bayesian would say “let’s use a prior that favors monotonicity but allows larger sample sizes to override this belief.”

Now that adaptive and sequential experiments are becoming more popular,
and a formal mechanism is needed to use data from one experiment to
inform a later experiment (a good example being the use of adult
clinical trial data to inform clinical trials on children when it is
difficult to enroll a sufficient number of children for the child data
to stand on their own), Bayes is needed more than ever. It took me a
while to realize something that is quite profound: A Bayesian solution
to a simple problem (e.g., 2-group comparison of means) can be embedded
into a complex design (e.g., adaptive clinical trial) **without
modification**. Frequentist solutions require highly complex
modifications to work in the adaptive trial setting.

I met likelihoodist Jeffrey Blume in 2008 and started to like the likelihood approach. It is more Bayesian than frequentist. I plan to learn more about this paradigm. Jeffrey has an excellent web site.

Several readers have asked me how I could believe all this and publish a
frequentist-based book such as *Regression Modeling Strategies*. There
are two primary reasons. First, I started writing the book before I
knew much about Bayes. Second, I performed a lot of simulation studies
that showed that purely empirical model-building had a low chance of
capturing clinical phenomena correctly and of validating on new
datasets. I worked extensively with cardiologists such as Rob Califf,
Dan Mark, Mark Hlatky, David Prior, and Phil Harris who give me the
ideas for injecting clinical knowledge into model specification. From
that experience I wrote *Regression Modeling Strategies* in the most
Bayesian way I could without actually using specific Bayesian methods.
I did this by emphasizing subject-matter-guided model specification.
The section in the book about specification of interaction terms is
perhaps the best example. When I teach the full-semester version of my
course I interject Bayesian counterparts to many of the techniques
covered.

There are challenges in moving more to a Bayesian approach. The ones I encounter most frequently are:

- Teaching clinical trialists to embrace Bayes when they already do in spirit but not operationally. Unlearning things is much more difficult than learning things.
- How to work with sponsors, regulators, and NIH principal investigators to specify the (usually skeptical) prior up front, and to specify the amount of applicability assumed for previous data.
- What is a Bayesian version of the multiple degree of freedom “chunk test”? Partitioning sums of squares or the log likelihood into components, e.g., combined test of interaction and combined test of nonlinearities, is very easy and natural in the frequentist setting.
- How do we specify priors for complex entities such as the degree of monotonicity of the effect of a continuous predictor in a regression model? The Bayesian approach to this will ultimately be more satisfying, but operationalizing this is not easy.

With new tools such as Stan and well written accessible books such as Kruschke’s and McElreath’s it’s getting to be easier to be Bayesian each day. For a longer list of suggested articles and books recommended for those without advanced statistics background see this. See also Richard McElreath’s online lectures and trialdesign.org. The R brms package, which uses Stan, makes a large class of regression models even more accessible. A large number of R scripts illustrating Bayesian analysis are here.

Another reason for moving from frequentism to Bayes is that frequentist ideas are so confusing that even expert statisticians frequently misunderstand them, and are tricked into dichotomous thinking because of the adoption of null hypothesis significance testing (NHST). The paper by BB McShane and D Gal in JASA demonstrates alarming errors in interpretation by many authors of JASA papers. If those with a high level of statistical training make frequent interpretation errors could frequentist statistics be fundamentally flawed? Yes! In McShane and Gal’s paper they described two surveys sent to authors of JASA, as well as to authors of articles not appearing in the statistical literature (luckily for statisticians the non-statisticians fared a bit worse). Some of their key findings are as follows.

- When a p-value is present, (primarily frequentist) statisticians
confuse population vs. sample, especially if the p-value is large.
Even when directly asked whether patients
*in this sample*fared batter on one treatment than the other, the respondents often answered according to whether or not p<0.05. Dichotomous thinking crept in. - When asked whether evidence from the data made it more or less likely that a drug is beneficial in the population, many statisticians again were swayed by the p-value and not tendencies indicated by the raw data. The failed to understand that your chances are improved by “playing the odds”, and gave different answers whether one was playing the odds for an unknown person vs. selecting treatment for themselves.
- In previous studies by the authors, they found that “applied researchers presented with not only a p-value but also with a posterior probability based on a noninformative prior were less likely to make dichotomization errors.”

The authors also echoed Wasserstein, Lazar, and Cobb’s concern that we are setting researchers up for failure: “we teach NHST because that’s what the scientific community and journal editors use but they use NHST because that’s what we teach them. Indeed, statistics at the undergraduate level as well as at the graduate level in applied fields is often taught in a rote and recipe-like manner that typically focuses exclusively on the NHST paradigm.”

Some of the problems with frequentist statistics are the way in which its methods are misused, especially with regard to dichotomization. But an approach that is so easy to misuse and which sacrifices direct inference in a futile attempt at objectivity still has fundamental problems.

I use the following slightly oversimplified equations to contrast frequentist and Bayesian inference.

- Frequentist = subjectivity
_{1}+ subjectivity_{2}+ objectivity + data + endless arguments about everything - Bayesian = subjectivity
_{1}+ subjectivity_{3}+ objectivity + data + endless arguments about one thing (the prior)

where

- subjectivity
_{1}= choice of the data model - subjectivity
_{2}= sample space and how repetitions of the experiment are envisioned, choice of the stopping rule, 1-tailed vs. 2-tailed tests, multiplicity adjustments, … - subjectivity
_{3}= prior distribution

Frank’s Plenary Session Podcast on Bayesian thinking.

Go here for discussions about this article that are not on this blog.

## Other Resources

- General resources
- Statistical Remedies for Medical Researchers by Peter Thall
- Bayesian estimation supersedes the t test by John Kruschke
- Bayesian t-tests
- Statistical Rethinking examples with R brms
- Michael Clark’s R and Stan example code
- Stephen Martin’s A foray into Bayesian handling of missing data with Stan
- Thomas Bayes and the crisis in science by David Papineau
- Bayesian theorists were little better than cranks by William Briggs.
- A student’s guide to Bayesian statistics by Ben Lambert
- Book for Lambert’s
*A Student’s Guide to Bayesian Statistics* - Data analysis: A Bayesian tutorial by Devinderjit Sivia and John Skilling
- Redefine Statistical Significance XVII by EJ Wagenmakers and Q Gronau
- Steve Ruberg’s Blog
- Dicing with the Unknown by Tony O’Hagan
- Reasons confidence intervals and credible intervals may not be equated by Ladislas Nalborczyk, Paul-Christian Bürkner, Donald R. Williams

## More Quotes

- Bayes: Distributional + prior assumption

Freq: Distributional + sampling dist assumption

You don’t need a prior to be ‘true’, you need it to be defendable. “Given this prior uncertainty, what do the data suggest?“

Can you defend the existence of a sampling distribution? - Stephen Martin - The thing is-Both frameworks can operate w/in counterfactual reasoning. “Assuming I am an extreme skeptic, this is what the data suggest”, for example. The nice thing about Bayes is that the counterfactual reasoning is immediate, rather than dependent on samples you’ll never see. - Stephen Martin