Statistical Thinking

This article is about a real example in which creation of a hybrid Bayesian-frequentist RCT design created an analytical mess.

2 min

Wedding Bayesian and Frequentist Designs Created a Mess

2023

inference

RCT

bayes

design

evidence

multiplicity

posterior

prior

sequential

Aug 21, 2023

This article briefly discusses why the rank difference test is better than the Wilcoxon signed-rank test for paired data, then shows how to generalize the rank difference test using the proportional odds ordinal logistic semiparametric regression model. To make the regression model work for non-independent (paired) measurements, the robust cluster sandwich covariance estimator is used for the log odds ratio. Power and type I assertion \(\alpha\) probabilities are compared with the paired \(t\)-test for \(n=25\). The ordinal model yields \(\alpha=0.05\) under the null and has power that is virtually as good as the optimum paired \(t\)-test. For non-normal data the ordinal model power exceeds that of the parametric test.

Ordinal Models for Paired Data

2023

ordinal

hypothesis-testing

inference

regression

Aug 16, 2023

This article provides resources to assist researchers in understanding and using ordinal regression models, and provides arguments for their wider use.

10 min

Resources for Ordinal Regression Models

2022

2023

endpoints

ordinal

regression

May 1, 2023

I describe seven common errors in decision curve analysis. Avoidance of such errors will make decision curve analysis more reliable and useful.

20 min

Seven Common Errors in Decision Curve Analysis

decision-making

diagnosis

medicine

2023

Mar 18, 2023

Andrew Vickers

Randomized clinical trials are successful because they do not mimic clinical practice. They remain highly clinically relevant despite this.

Randomized Clinical Trials Do Not Mimic Clinical Practice, Thank Goodness

generalizability

design

medicine

RCT

drug-evaluation

personalized-medicine

evidence

2017

2023

Feb 14, 2023

This is an example statistical plan for project proposals where the goal is to develop a biostatistical model for prediction, and to do external or strong internal validation of the model.

20 min

Biostatistical Modeling Plan

2023

accuracy-score

endpoints

ordinal

collaboration

data-reduction

design

medicine

prediction

regression

validation

bootstrap

Jan 26, 2023

This article covers some of the bad statistical practices that have crept into biomarker research, including setting the bar too low for demonstrating that biomarker information is new, believing that winning biomarkers are really “winners”, and improper use of continuous variables. Step-by-step guidance is given for ensuring that a biomarker analysis is not reproducible and does not provide clinically useful information.

How to Do Bad Biomarker Research

2022

big-data

bioinformatics

biomarker

bootstrap

data-science

decision-making

dichotomization

forward-probability

generalizability

medical-literature

multiplicity

personalized-medicine

prediction

principles

reporting

reproducible

responder-analysis

sample-size

sensitivity

Oct 6, 2022

An overview of R Workflow, which covers how to use R effectively all the way from importing data to analysis, and making use of Quarto for reproducible reporting.

R Workflow

2022

data-science

graphics

reproducible

Jun 25, 2022

This article examines the benefits of decision curve analysis for assessing model performance when adding a new marker to an existing model. Decision curve analysis provides a clinically interpretable metric based on the number of events identified and interventions avoided.

Decision curve analysis for quantifying the additional benefit of a new marker

2022

biomarker

accuracy-score

decision-making

diagnosis

medicine

Apr 11, 2022

Emily Vertosick and Andrew Vickers

In this article I provide much more extensive simulations showing the near perfect agreement between the odds ratio (OR) from a proportional odds (PO) model, and the Wilcoxon two-sample test statistic. The agreement is studied by degree of violation of the PO assumption and by the sample size. A refinement in the conversion formula between the OR and the Wilcoxon statistic scaled to 0-1 (corcordance probability) is provided.

Equivalence of Wilcoxon Statistic and Proportional Odds Model

2022

endpoints

ordinal

drug-evaluation

hypothesis-testing

RCT

regression

Apr 6, 2022

Most analysts automatically turn towards random effects models when analyzing longitudinal data. This may not always be the most natural, or best fitting approach.

24 min

Longitudinal Data: Think Serial Correlation First, Random Effects Second

drug-evaluation

endpoints

measurement

RCT

regression

2022

Mar 15, 2022

This article demonstrates how the proportional odds (PO) assumption and its impact can be assessed. General robustness to non-PO on either a main variable of interest or on an adjustment covariate are exemplified. Advantages of a continuous Bayesian blend of PO and non-PO are also discussed.

Assessing the Proportional Odds Assumption and Its Impact

2022

accuracy-score

dichotomization

endpoints

ordinal

Mar 9, 2022

We compare decision curve analysis and traditional decision analysis to illustrate their similarities and differences.

27 min

A Comparison of Decision Curve Analysis with Traditional Decision Analysis

decision-making

diagnosis

medicine

2021

Dec 27, 2021

Andrew Vickers

This is a commentary on the paper by Benkeser, Díaz, Luedtke, Segal, Scharfstein, and Rosenblum

Commentary on Improving Precision and Power in Randomized Trials for COVID-19 Treatments Using Covariate Adjustment, for Binary, Ordinal, and Time-to-Event Outcomes

bayes

covid-19

design

generalizability

inference

metrics

ordinal

personalized-medicine

RCT

regression

reporting

2021

Jul 17, 2021

Frank Harrell, Stephen Senn

25 min

Incorrect Covariate Adjustment May Be More Correct than Adjusted Marginal Estimates

2021

generalizability

RCT

regression

This article provides a demonstration that the perceived non-robustness of nonlinear models for covariate adjustment in randomized trials may be less of an issue than the non-transportability of marginal so-called robust estimators.

Jun 29, 2021

This article presents an argument that for RCTs with a binary outcome the primary result should be a distribution and not any single number summary. The GUSTO-I study is used to exemplify risk difference distributions.

17 min

Avoiding One-Number Summaries of Treatment Effects for RCTs with Binary Outcomes

2021

generalizability

RCT

regression

Jun 28, 2021

Since the Wilcoxon test is a special case of the proportional odds (PO) model, if one likes the Wilcoxon test, one must like the PO model. This is made more convincing by showing examples of how one may accurately compute the Wilcoxon statistic from the PO model’s odds ratio.

10 min

If You Like the Wilcoxon Test You Must Like the Proportional Odds Model

ordinal

hypothesis-testing

2021

accuracy-score

RCT

regression

metrics

Mar 10, 2021

The recent PATH (Predictive Approaches to Treatment effect Heterogeneity) Statement outlines principles, criteria, and key considerations for applying predictive approaches to clinical trials to provide patient-centered evidence in support of decision making. Here challenges in implementing the PATH Statement are addressed with the GUSTO-I trial as a case study.

Implementation of the PATH Statement

Nov 24, 2020

Ewout Steyerberg

19 min

Violation of Proportional Odds is Not Fatal

2020

ordinal

accuracy-score

RCT

regression

hypothesis-testing

metrics

Many researchers worry about violations of the proportional hazards assumption when comparing treatments in a randomized study. Besides the fact that this frequently makes them turn to a much worse approach, the harm done by violations of the proportional odds assumption usually do not prevent the proportional odds model from providing a reasonable treatment effect assessment.

Sep 20, 2020

This article discusses issues with unadjusted effect ratios such as odds ratios and hazard ratios, showing a simple example of non-generalizability of unadjusted odds ratios.

Unadjusted Odds Ratios are Conditional

2020

generalizability

RCT

regression

Sep 13, 2020

This article summarizes arguments for the claim that the primary analysis of treatment effect in a RCT should be with adjustment for baseline covariates. It reiterates some findings and statements from classic papers, with illustration on the GUSTO-I trial.

9 min

RCT Analyses With Covariate Adjustment

2020

drug-evaluation

generalizability

medicine

personalized-medicine

prediction

RCT

regression

Jul 19, 2020

Ewout Steyerberg
@ESteyerberg

13 min

Bayesian Methods to Address Clinical Development Challenges for COVID-19 Drugs and Biologics

bayes

RCT

design

drug-evaluation

medicine

responder-analysis

covid-19

The COVID-19 pandemic has elevated the challenge for designing and executing clinical trials with vaccines and drug/device combinations within a substantially shortened time frame. Numerous challenges in designing COVID-19 trials include lack of prior data for candidate interventions / vaccines due to the novelty of the disease, evolving standard of care and sense of urgency to speed up development programmes. We propose sequential and adaptive Bayesian trial designs to help address the challenges inherent in COVID-19 trials. In the Bayesian framework, several methodologies can be implemented to address the complexity of the primary endpoint choice. Different options could be used for the primary analysis of the WHO Severity Scale, frequently used in COVID-19 trials. We propose the longitudinal proportional odds mixed effects model using the WHO Severity Scale ordinal scale. This enables efficient utilization of all clinical information to optimize sample sizes and maximize the rate of acquiring evidence about treatment effects and harms.

May 29, 2020

Natalia Muhlemann MD, Rajat Mukherjee Phd, Frank Harrell PhD

This article explains how the generalizability of randomized trial findings depends primarily on whether and how patient characteristics modify (interact with) the treatment effect. For an observational study this will be related to overlap in the propensity to receive treatment.

Implications of Interactions in Treatment Comparisons

RCT

drug-evaluation

generalizability

medicine

observational

personalized-medicine

prediction

subgroup

2020

Mar 3, 2020

Reasons are given for why heterogeneity of treatment effect must be demonstrated, not assumed. An example is presented that shows that HTE must exceed a certain level before personalizing treatment results in better decisions than using the average treatment effect for everyone.

25 min

The Burden of Demonstrating HTE

RCT

generalizability

medicine

metrics

personalized-medicine

subgroup

2019

Apr 8, 2019

This article shows an example formally testing for heterogeneity of treatment effect in the GUSTO-I trial, shows how to use penalized estimation to obtain patient-specific efficacy, and studies variation across patients in three measures of treatment effect.

Assessing Heterogeneity of Treatment Effect, Estimating Patient-Specific Efficacy, and Studying Variation in Odds ratios, Risk Ratios, and Risk Differences

RCT

generalizability

medicine

metrics

personalized-medicine

prediction

subgroup

accuracy-score

2019

Mar 25, 2019

Researchers have used contorted, inefficient, and arbitrary analyses to demonstrated added value in biomarkers, genes, and new lab measurements. Traditional statistical measures have always been up to the task, and are more powerful and more flexible. It’s time to revisit them, and to add a few slight twists to make them more helpful.

Statistically Efficient Ways to Quantify Added Predictive Value of New Measurements

prediction

sample-size

validation

accuracy-score

biomarker

diagnosis

medicine

reporting

2018

Oct 17, 2018

The performance metrics chosen for prediction tools, and for Machine Learning in particular, have significant implications for health care and a penetrating understanding of the AUROC will lead to better methods, greater ML value, and ultimately, benefit patients.

18 min

In Machine Learning Predictions for Health Care the Confusion Matrix is a Matrix of Confusion

data-science

machine-learning

prediction

2018

Aug 28, 2018

Drew Griffin Levy
@DrewLevy

24 min

Data Methods Discussion Site

collaboration

teaching

2018

This article lays out the rationale and overall design of a new discussion site about quantitative methods.

Jun 19, 2018

This article provides my reflections after the PCORI/PACE Evidence and the Individual Patient meeting on 2018-05-31. The discussion includes a high-level view of heterogeneity of treatment effect in optimizing treatment for individual patients.

Viewpoints on Heterogeneity of Treatment Effect and Precision Medicine

RCT

biomarker

decision-making

drug-evaluation

generalizability

medicine

metrics

personalized-medicine

prediction

subgroup

2018

Jun 4, 2018

This article elaborates on Frank Harrell’s post providing guidance in choosing between machine learning and statistical modeling for a prediction project.

16 min

Navigating Statistical Modeling and Machine Learning

data-science

machine-learning

prediction

2018

May 14, 2018

Drew Griffin Levy
@DrewLevy

11 min

Road Map for Choosing Between Statistical Modeling and Machine Learning

data-science

machine-learning

prediction

2018

This article provides general guidance to help researchers choose between machine learning and statistical modeling for a prediction project.

Apr 30, 2018

This article discusses issues related to alpha spending, effect sizes used in power calculations, multiple endpoints in RCTs, and endpoint labeling. Changes in endpoint priority is addressed. Included in the the discussion is how Bayesian probabilities more naturally allow one to answer multiple questions without all-too-arbitrary designations of endpoints as “primary” and “secondary”. And we should not quit trying to learn.

10 min

Musings on Multiple Endpoints in RCTs

RCT

bayes

design

drug-evaluation

evidence

hypothesis-testing

medicine

multiplicity

p-value

posterior

endpoints

2018

Mar 26, 2018

What are the major elements of learning from data that should inform the research process? How can we prevent having false confidence from statistical analysis? Does a Bayesian approach result in more honest answers to research questions? Is learning inherently subjective anyway, so we need to stop criticizing Bayesians’ subjectivity? How important and possible is pre-specification? When should replication be required? These and other questions are discussed.

13 min

Improving Research Through Safer Learning from Data

design

evidence

generalizability

inference

judgment

measurement

prior

bayes

2018

Mar 8, 2018

Deep learning and other forms of machine learning are getting a lot of press in medicine. The reality doesn’t match the hype, and interpretable statistical models still have a lot to offer.

Is Medicine Mesmerized by Machine Learning?

machine-learning

accuracy-score

classification

data-science

decision-making

medicine

prediction

validation

2018

Feb 1, 2018

This article gives examples of information gained by using ordinal over binary response variables. This is done by showing that for the same sample size and power, smaller effects can be detected.

11 min

Information Gain From Using Ordinal Instead of Binary Outcomes

RCT

design

ordinal

dichotomization

inference

precision

responder-analysis

sample-size

2018

Jan 28, 2018

I prefer fractions and ratios over percents. Here are the reasons.

Why I Don’t Like Percents

metrics

2018

Jan 19, 2018

It is easy to compute the sample size N₁ needed to reliably estimate how one predictor relates to an outcome. It is next to impossible for a machine learning algorithm entertaining hundreds of features to yield reliable answers when the sample size < N₁.

How Can Machine Learning be Reliable When the Sample is Adequate for Only One Feature?

prediction

machine-learning

sample-size

validation

precision

accuracy-score

2018

Jan 11, 2018

Methodologic goals and wishes for research and clinical practice for 2018

11 min

New Year Goals

2018

2019

Dec 29, 2017

This article addresses data reduction, also called unsupervised learning.

Scoring Multiple Variables, Too Many Variables and Too Few Observations: Data Reduction

variability

data-reduction

2017

Nov 21, 2017

Criticism of medical journal articles is easy. I need to keep in mind that much good research is done even if there are some flaws in the design, analysis, or interpretation. I also need to remember that real people are involved.

Statistical Criticism is Easy; I Need to Remember That Real People are Involved

RCT

2017

Nov 5, 2017

This article describes the drastically different way that sequential data looks operate in a Bayesian setting compared to a classical frequentist setting.

Continuous Learning from Data: No Multiplicities from Computing and Using Bayesian Posterior Probabilities as Often as Desired

bayes

sequential

RCT

2017

Oct 9, 2017

This article contrasts language used when reporting a classical frequentist treatment comparison vs. a Bayesian one, and describes why Bayesian statements convey more actionable information.

13 min

Bayesian vs. Frequentist Statements About Treatment Efficacy

reporting

inference

p-value

RCT

bayes

drug-evaluation

evidence

hypothesis-testing

2017

Oct 4, 2017

In this article I seek recommendations for integrating various media for teaching long courses.

Integrating Audio, Video, and Discussion Boards with Course Notes

collaboration

teaching

reproducible

2017

Aug 1, 2017

Observational data from electronic health records may contain biases that large sample sizes do not overcome. Moderate confounding by indication may render an infinitely large observational study less useful than a small randomized trial for estimating relative treatment effectiveness.

EHRs and RCTs: Outcome Prediction vs. Optimal Treatment Selection

prediction

generalizability

drug-evaluation

evidence

subgroup

EHR

design

medicine

inference

big-data

RCT

personalized-medicine

2017

Jun 1, 2017

Frank Harrell, Laura Lazzeroni

16 min

Statistical Errors in the Medical Literature

prediction

logic

p-value

validation

bayes

evidence

subgroup

dichotomization

medicine

inference

change-scores

RCT

personalized-medicine

responder-analysis

hypothesis-testing

medical-literature

2017

This article catalogs several types of statistical problems that occur frequently in the medical journal articles.

Apr 8, 2017

This is a subjective ranking of topical areas by the typical quality of research published in the area. Keep in mind that top-quality research can occur in any area when the research team is multi-disciplinary, team members are at the top of their game, and peer review is functional.

32 min

Subjective Ranking of Quality of Research by Subject Matter Area

2017

Mar 16, 2017

Estimating tendencies is usually a more appropriate goal than classification, and classification leads to the use of discontinuous accuracy scores which give rise to misleading results.

Damage Caused by Classification Accuracy and Other Discontinuous Improper Accuracy Scoring Rules

prediction

machine-learning

accuracy-score

dichotomization

probability

bioinformatics

validation

classification

data-science

2017

Mar 1, 2017

This is the story of what influenced me to become a Bayesian statistician after being trained as a classical frequentist statistician, and practicing only that mode of statistics for many years.

5 min

My Journey from Frequentist to Bayesian Statistics

inference

p-value

likelihood

RCT

bayes

multiplicity

posterior

drug-evaluation

principles

evidence

hypothesis-testing

2017

Feb 19, 2017

With interactive graphics one can start by showing the most important data features, then drill down to see details.

24 min

Interactive Statistical Graphics: Showing More By Showing Less

survival-analysis

graphics

2017

Feb 5, 2017

p-values are very often misinterpreted. p-values and null hypothesis significant testing have hurt science. This article attempts to catalog all the ways in which these happen.

3 min

A Litany of Problems With p-values

decision-making

bayes

multiplicity

p-value

hypothesis-testing

2017

Feb 5, 2017

The error of the transposed conditional is rampant in research. Conditioning on what is unknowable to predict what is already known leads to a host of complexities and interpretation problems.

36 min

Clinicians’ Misunderstanding of Probabilities Makes Them Like Backwards Probabilities Such As Sensitivity, Specificity, and Type I Error

specificity

probability

backward-probability

forward-probability

p-value

bayes

conditioning

diagnosis

decision-making

dichotomization

medicine

bioinformatics

biomarker

sensitivity

posterior

accuracy-score

classification

2017

Jan 25, 2017

The many disadvantages of split-sample validation, including subtle ones, are discussed.

Split-Sample Model Validation

prediction

bootstrap

validation

2017

Jan 23, 2017

This brief note catalogs what I feel are some of the most important principles to guide statistical practice.

Fundamental Principles of Statistics

design

measurement

principles

2017

Jan 18, 2017

Suggestions for future articles, by readers

3 min

Ideas for Future Articles

2017

Jan 16, 2017

Classification involves a forced-choice premature decision, and is often misused in machine learning applications. Probability modeling involves the quantification of tendencies and usually addresses the real project goals.

2 min

Classification vs. Prediction

prediction

decision-making

machine-learning

accuracy-score

classification

data-science

2017

Jan 15, 2017

This article explains why for decision making the original idea of null hypothesis testing never delivered on its goal.

Null Hypothesis Significance Testing Never Worked

logic

inference

bayes

p-value

hypothesis-testing

inductive-reasoning

2017

Jan 14, 2017

p-values are not what decision makers need, nor are they what most decision makers think they are getting.

3 min

p-values and Type I Errors are Not the Probabilities We Need

judgment

inference

likelihood

bayes

multiplicity

p-value

prior

hypothesis-testing

2017

Jan 14, 2017

Introducing the Statistical Thinking Blog

Introduction

2017

principles

Jan 13, 2017

For many years biostatistics had been successful at Vanderbilt, but the opportunity to create a department home for biostatistics was too good to pass up. The new department and its support from the School of Medicine leadership made it an attractive place for recruiting new faculty and staff. This talk will cover what made the department attractive, as well as principles upon which the Department of Biostatistics was founded in the Vanderbilt School of Medicine in 2003. These principles include reproducible research and prioritizing collaboration over consultation. Challenges and opportunities of running the department in a growing academic medical center will be discussed, with emphasis on generalizable knowledge that may assist others in starting, sustaining, and enhancing biostatistics groups in their own medical centers.

Talks

My Big Jump: Founding a Department of Biostatistics

2023

collaboration

medicine

reproducible

Mar 20, 2023

This talk covers a variety of controversial and/or current issues related to statistical modeling and prediction research. Some of the topics covered are why external validation is often not a good idea, why validating researchers is often more efficient than validating models, what distinguishes statistical models from machine learning, how variable selection only gives the illusion of learning from data, and advantages of older measures of model performance.

Controversies in Predictive Modeling, Machine Learning, and Validation

prediction

machine-learning

validation

regression

Sep 28, 2022

This work is intended to foster best practices in reproducible data documentation and manipulation, statistical analysis, graphics, and reporting. It will enable the reader to efficiently produce attractive, readable, and reproducible research reports while keeping code concise and clear. Readers are also guided in choosing statistically efficient descriptive analyses that are consonant with the type of data being analyzed.

R Workflow for Reproducible Biomedical Research Using Quarto

data-science

reporting

reproducible

Sep 26, 2022

Univariate ordinal models can be used to model a wide variety of longitudinal outcomes, using only standard software, through the use of Markov processes. This talk will show how longitudinal ordinal models unify a wide variety of types of analyses including time to event, recurrent events, continuous responses interrupted by events, and multiple events that are capable of being placed in a hierarchy. Through the use of marginalization over the previous state in an ordinal multi-state transition model, one may obtain virtually any estimand of interest. Both frequentist and Bayesian methods can be used to fit the model and draw inferences.

Longitudinal Ordinal Models as a General Framework for Medical Outcomes

endpoints

RCT

ordinal

regression

Dec 18, 2021

This presentation covers several ways to make clinical trials more efficient and to reduce the chance of ending with an equivocal result. Some of the approaches covered are Bayesian sequential designs allowing for study extension if results are promising, not being tied by type I assertion probabilities/α spending, using high-information longitudinal ordinal outcomes, and covariate adjustment.

Modernizing Clinical Trial Design and Analysis to Improve Efficiency & Flexibility

RCT

drug-development

bayes

regression

endpoints

Nov 4, 2021

Health researchers and practicing clinicians are with increasing frequency hearing about machine learning (ML) and artificial intelligence applications. They, along with many statisticians, are unsure of when to use traditional statistical models (SM) as opposed to ML to solve analytical problems related to diagnosis, prognosis, treatment selection, and health outcomes. And many advocates of ML do not know enough about SM to be able to appropriately compare performance of SM and ML. ML experts are particularly prone to not grasp the impact of the choice of measures of predictive performance. In this talk I attempt to define what makes ML distinct from SM, and to define the characteristics of applications for which ML is likely to offer advantages over SM, and vice-versa. The talk will also touch on the vast difference between prediction and classification and how this leads to many misunderstandings in the ML world. Other topics to be convered include the minimum sample size needed for ML, and problems ML algorithms have with absolute predictive accuracy (calibration).

Musings on Statistical Models vs. Machine Learning in Health Research

regression

prediction

machine-learning

validation

classification

accuracy-score

data-science

Jun 9, 2021

Continuous learning from data and computation of probabilities that are directly applicable to decision making in the face of uncertainty are hallmarks of the Bayesian approach. Bayesian sequential designs are the simplest of flexible designs, and continuous learning capitalizes on their efficiency, resulting in lower expected sample sizes until sufficient evidence is accrued due to the ability to take unlimited data looks. Classical null hypothesis testing only provides evidence against the supposition that a treatment has exactly zero effect, and it requires one to deal with complexities if not doing the analysis at a single fixed time. Bayesian posterior probabilities, on the other hand, can be computed at any point in the trial and provide current evidence about all possible questions, such as benefit, clinically relevant benefit, harm, and similarity of treatments.

Besides requiring flexibility in a rapidly changing environment, COVID-19 trials often use ordinal endpoints and standard statistical models such as the proportional odds (PO) model. Less standard is how to model serial ordinal responses. Methods and new Baysian software have been developed for COVID-19 trials. Also implemented is a Bayesian partial PO model (Peterson and Harrell, 1990) that allows one to put a prior on the degree to which a treatment affects mortality differently than how it affects other components of the ordinal scale. These ordinal models will be briefly discussed.

Sequential Bayesian Designs for Rapid Learning in COVID-19 Clinical Trials

bayes

RCT

covid-19

Nov 25, 2020

This presentation clarifies what type I assertion probability α protects against, by making a clear distinction between how often we assert an effect vs. how often we are wrong about an effect. It is argued that “error” should be struck from the phrase “type I error probability”. Frequentist and Bayesian approaches will be briefly contrasted, with an explanation of why it is confusing to mix the two. Terms such as p-values, α, and “false positive” will be attempted to be precisely defined, and subtleties in defining “false positive probability” will be discussed. Then emphasis is placed on multiplicity issues that can occur when analyzing data multiple times, and why such issues do not apply to the Bayesian paradigm. By way of pattern recognition, medical diagnosis, and sequential clinical trial examples it is explained why α loses relevance once data are available.

Controlling α vs. Probability of a Decision Error

Nov 13, 2020

Bayes for Flexibility in Urgent Times

bayes

RCT

drug-development

covid-19

Jul 1, 2020

This presentation covers the limitations of frequentist inference for answering clinical questions and generating evidence for efficacy. Key to understanding efficacy is understanding conditional probability and its relation to information flow. What type I error really controls is discussed, and it is argued that it is not regulator’s regret. The frequentist and Bayesian approaches for stating statistical results for efficacy assesment are contrasted, and a high-level view of the Bayesian approach is given. A key point is the actionability of the statistical results. Some of the advantages of the Bayesian approach are cataloged, with emphasis on forward-information-flow probabilities that instantly define their own error probabilities. Multiplicity non-issues are discussed.

Fundamental Advantages of Bayes in Drug Development

bayes

inference

multiplicity

drug-development

RCT

Apr 27, 2020

This interview by Ellie Murray and Lucy D’Agostino McGowan for their Casual Inference podcast recorded 2020-02-26 is titled Getting Bayesian

Casual Inference Podcast

bayes

Apr 23, 2020

For clinical trials a good deal of effort goes into producing both final trial reports and interim reports for data monitoring committees, and experience has shown that reviewers much prefer graphical to tabular reports. Interactive graphical reports go a step further and allow the most important information to be presented by default, while inviting the reviewer to drill down to see other details. The drill-down capability, implemented by hover text using the R plotly package, allows one to almost entirely dispense with tables because the hover text can contain the part of a table that pertains to the reviewer’s current focal point in the graphical display, among other things. Also, there are major efficiency gains by having a high-level language for producing common elements of reports related to accrual, exclusions, descriptive statistics, adverse events, time to event, and longitudinal data. This talk will overview the hreport package, which relies on R, RMarkdown, knitr, plotly, Hmisc, and HTML5. RStudio is an ideal report developement environment for using these tools.

R for Graphical Clinical Trial Reporting

RCT

reporting

safety

Jan 29, 2020

Why Bayes for Clinical Trials?

bayes

RCT

drug-development

Sep 20, 2019

Statisticians and statistical programmers spend a great deal of time analyzing data and producing reports for clinical trials, both for final trial reports and for interim reports for data monitoring committees. Point and Click interfaces and copy-and-paste are now believed to be bad models for reproducible research. Instead, there are advantages to developing a high-level language for producing common elements of reports related to accrual, exclusions, descriptive statistics, adverse events, time to event, and longitudinal data.

It is well appreciated in the statistical and graphics design communities that graphics are much better than tables for conveying numeric information. There are thus advantages for having statistical reports for clinical trials that are almost completely graphical. Instead of devoting space to tables, HTML5 and Javascript in R html reports makes it easy to show tabular information in pop-up text when hovering the mouse over a graphical element.

In this talk I will describe R packages greport (using a \(\LaTeX\) pdf model) and hreport (using an html model). knitr and Rmarkdown are used to compose the reproducible reports. greport and hreport compose all figure and table captions. They contain high-level abstractions of common clinical trial reporting tasks to minimize programming by the use. Before showing examples of these report-making packages, I’ll show some of the new graphical building blocks in the Hmisc and rms packages. These new functions make use of the plotly package to create interactive graphics using Javascript and D3.

R for Clinical Trial Reporting

RCT

reporting

Sep 13, 2019

This interview by Vinay Prasad for his Plenary Session podcast discusses Bayesian thinking, especially about clinical trials.

Bayesian Thinking Podcast

bayes

RCT

drug-development

Aug 7, 2019

Regression Modeling Strategies

prediction

validation

accuracy-score

machine-learning

regression

Short course

May 3, 2019

Feature selection in the large p non-large n case is known to be unreliable, but most biomedical researchers are not aware of the magnitude of the problem. They assume for example that setting a false discovery rate makes the results reliable, forgetting about the false negative rate and decades of research showing unreliability of stepwise variable selection even in the low p case. A related problem is the unreliability in the estimate of the effect (e.g., an odds ratio) of a feature found by selecting ‘winners’. This talk will demonstrate some simple bootstrap and Monte Carlo simulation procedures for teaching biomedical researchers how to quantify these problems. One of the bootstrap examples exposes the difficulty of the task by computing confidence intervals for importance rankings of features.

Simple Bootstrap and Simulation Approaches to Quantifying Reliability of High-Dimensional Feature Selection

big-data

bioinformatics

machine-learning

multiplicity

prediction

regression

validation

Jul 31, 2018

This talk covers a variety of topics in clinical prediction modeling, with emphasis on quantifying the added value of new predictors.

Current Challenges and Opportunities in Clinical Prediction Modeling

prediction

accuracy-score

validation

Jul 4, 2018

The Vanderbilt Department of Biostatistics has two policies currently in effect:
1. All statistical reports will be reproducible
2. All reports should include all the code used to produce the report, in some fashion

We have succeeded with 1. (mainly using knitr in R) and to a large extent with 2. Some biostatisticians have been concerned about interspersing code with the contents of the report. It has also been challenging to copy some PDF report components (e.g., advanced tables) into word processing documents.

Fortunately R and RStudio have recently added a number of new features that allow for easy creation of HTML notebooks that are viewed with any web browser. This solves the problems listed above and adds new possibilities such as interactive graphics that appear in a self-contained HTML file to post on a collaboration web server or send to a collaborator. Interactive graphics allow the analyst to create more detail (e.g., confidence bands for multiple confidence levels; confidence bands for group differences as well as those for each group individually) with the collaborator able to easily select which details to view.

I have made major revisions in the R Hmisc and rms packages to provide new capabilities that fit into the R/RStudio Rmarkdown HTML notebook framework. Interactive plotly graphics (based on Javascript and D3) and customized HTML output are the main new ingredients. In this talk the rationale for this approach is discussed, and the new features are demonstrated with two statistical reports. A few miscellaneous topics will also be covered, e.g. how to cite bibliographic references in Rmarkdown and how to interface R to citeulike.org for viewing or extracting bibliographic references.

For more information see

https://www.r-project.org
https://www.rstudio.com
http://rmarkdown.rstudio.com
http://rmarkdown.rstudio.com/r_notebooks.html
http://yihui.name/knitr
https://hbiostat.org/R/Hmisc
https://plot.ly/r
https://plot.ly/r/getting-started
ggplotly: a function that converts any ggplot2 graphic to a plotly interactive graphic: https://plot.ly/ggplot2

Using R, Rmarkdown, RStudio, knitr, plotly, and HTML for the Next Generation of Reproducible Statistical Reports

reporting

reproducible

Nov 16, 2017

It is difficult to design a clinical study to provide sound inferences about safety effects of drugs in addition to providing trustworthy evidence for efficacy. Patient entry criteria and experimental design are targeted at efficacy, and there are too many possible safety endpoints to be able to control type I error while preserving power. Safety analysis tends to be somewhat ad hoc and exploratory. But with the large quantity of safety data acquired during clinical drug testing, safety data are rarely harvested to their fullest potential. Also, decisions are sometimes made that result in analyses that are somewhat arbitrary or that lose statistical efficiency. For example, safety assessments can be too quick to rely on the proportion of patients in each treatment group at each clinic visit who have a lab measurement above two or three times the upper limit of normal.

Safety reports frequently fail to fully explore areas such as
• which types of patients are having AEs?
• what distortions in the tails of the distribution of lab values are taking place?
• which AEs tend to occur in the same patient?
• how to clinical AEs correlate to continuous lab measurements at a given time
• which AEs and lab abnormalities are uniquely related to treatment assigned?
• do preclinically significant measurements at an earlier visit predict AEs at a later visit?
• how can time trends in many variables be digested into an understandable picture?

This talk will demonstrate some of the exploratory statistical and graphical methods that can help answer questions such as the above, using examples based on data from real pharmaceutical trials.

Exploratory Analysis of Clinical Safety Data to Detect Safety Signals

RCT

safety

drug-evaluation

Jun 8, 2006